The scientific research groups of the Department:

  1. Extracellular Vesicle Research Group
  2. Medical Genomics Research Group
  3. Chemotaxis Research Group
  4. Experimental Rheumatology Research Group
  5. MTA-SE "Lendület" Experimental and Translational Immunimics Research Group

 


Extracellular Vesicle Research Group (head: Dr. Edit BUZÁS, University Professor, MD, PhD, DSc, med. habil.)

One of the major research areas of the Extracellular Vesicle Research Group is the role of post-synthetic protein- and lipid modifications (e.g. glycosylation, citrullination and oxidation) in the development of (auto)immune response (with special focus on rheumatoid arthritis). The other major research field of the group is the investigation of cell-derived membrane vesicles (exosomes, microvesicles and apoptotic bodies). We primarily focus on the role of membrane vesicles in autoimmunity and fetomaternal communication as well as on their stem cell biology and tumor immunology aspects.  The Inflammation Immunology/Membrane Vesicle Research Group participates in the Standardization of Pre-Analytical Variables of Plasma Microparticle Determination Workshop. The infrastructural background of membrane vesicle isolation is supported by Baross Gábor Infrastructural Development Program.

 


Medical Genomics Research Group (head: Dr. Csaba SZALAI, University professor, PhD, DSc, med. habil.)

The Medical Genomics Research Group investigates the genomic and pharmacogenomic background and pathomechanism of the following multifactorial diseases: asthma, allergy and acute lymphoblastic leukemia. For our researches we use our asthma and childhood leukemia bio- and databanks, which are registered in the Hungarian NEKIFUT as strategic research infrastructures. In collaboration with the Department of Measurement and Information Systems of Budapest University of Technology and Economics, the group also participates in developing bioinformatic tools important for our researches.

 


Chemotaxis Research Group (head: Dr. László KŐHIDAI, MD, PhD, med.habil.)

Main research fields investigated in Chemotaxis Research Group are

  • (i) research on cell adhesion, chemotaxis and other basic cell physiological responses;  
  • (ii) phylogeny of cell signaling - studies in ciliated model cells;
  • (iii) characterization of 'Chemotaxome', the novel category of systems biology.

An underlined, ongoing  project of the Research Group is to develop conjugates of drug-targeting available for different kinds of molecular delivery (chemotactic drug targeting) in tumors, atherosclerosis etc. The most significant models are unicellular eukaryotes (Tetrahymena pyriformis) as well as several mammalian tumor cell lines.   The Research Group is the host of the core facility of impedance based cell analytical research infrastructure (ECIS, xCELLignece) qualified as SKI by NEKIFUT/NKTH.  

 


MTA-SE "Lendület" Experimental and Translational Immunomics Research Group (head: Dr. Zoltán PÓS, PhD)

The Hungarian Academy of Sciences - Semmelweis Unversity ”Lendület” Experimental and Translational Immunomics Research Group, established in July 2012, conducts multidisciplinary research in the fields of immunology and genomics, with most of its efforts focused on the analysis of the recently discovered CD8+ T regional memory (Trm) cells, and related local immune responses. The group investigates these questions using automated isolation of organ-resident T memory and effector cells, genomic scale description of their organ-specific characteristics, and tracking in vivo T cell activity and movement, using both transgenic mouse models and human clinical samples.   

 

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