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LupsaN

Position: Research Assistant
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Room: NET 709
Phone: +36 (1) 210 2930 / 56435
   

 

 

CV

Birth: 1987


Education:

  • University of Szeged, Faculty of Science and Informatics, Molecular biologist 2011


Present and previous positions:

  • March 2016- Research assistant
    Semmelweis University, Department of Genetics, Cell-and Immunobiology, Experimental and Translational Immunomics Research Group
  • March 2013- 2016 PhD student
    Semmelweis University, Department of Genetics, Cell- and Immunobiology
  • October 2012- 2013 Research assistant
    University of Debrecen, DEOEC, Department of Pediatric Immunology and Infectious Diseases
  • September 2011-
    October 2012 PhD student at the Biological Research Centre (BRC), Hungarian Academy of Sciences Szeged, Membrane and Stress Biology Unit, Institute of Biochemistry, University of Szeged, Faculty of Medicine
  • June 2011-
    September 2011 Assistant
    Biological Research Centre (BRC), Hungarian Academy of Sciences, Szeged Membrane and Stress Biology Unit, Institute of Biochemistry Laboratory of Conformational Diseases
  • 2010-2011 Thesis writer
    Biological Research Centre (BRC), Hungarian Academy of Sciences, Szeged, Membrane and Stress Biology Unit, Institute of Biochemistry Laboratory of Conformational Diseases
  • 2009-2010 Exchange student
    Department of Biological Sciences Ecology and Genetics: Drosophila Behavior Group
  • 2008-2009 Student
    Department of Biochemistry and Molecular Biology Szeged


Professional visits:

  • 2009-2010 University of Aarhus Denmark, Erasmus exchange student and professional laboratory practice


Scholarship and awards:

  • Semmelweis University Research Excellence Award 2017
  • BioLegend Abstract Award 2016 2nd price
  • Travel grant from Molecular Medicine Doctoral School, Semmelweis University 2015
  • EFIS Travel Grants for ECI 2015
  • European Campus of Excellence, Host-microbe symbioses–old friends and foes fully funded scholarship and travel grant 2015


Memberships:

  • Hungarian Society for Immunology from 2014


Activities in education:

  • Immunology (Autumn semester), Genetics (Spring semester) practices in Immunology, Genetics and Genomics for Hungarian and English medical students in the sixth and the seventh semesters.


Research interests:

  • acute graft versus host disease (aGvHD)
  • activated CD8+ T cells
  • tissue specific homing and biomarkers
  • microbiome
  • aGvHD models


Research areas:

Acute graft versus host disease (aGVHD) developed upon aHSCT is understood as a rather complex disease driven by, among others, the appearance of CD8+T cells homing to and damaging various target organs of the recipient, most frequently the skin and the gastrointestinal tract. Studying aGvHD provides a unique opportunity to gain insight into the induction and regulation of T cell organotropism in a single, clinically also relevant experimental system. The main question raised by in our project is whether it is possible to define novel biomarkers of CD8+ T cells, homing to distinct organs and prognostic markers of acute GVHD as such, and its cutaneous and gastrointestinal forms in particular, by applying such an integrative research approach, and analyzing multiple, functionally linked insults affecting the host.
Ongoing projects are, as follows: parallel, follow-up analysis of the host’s microbiome by metagenome-sequencing, peripheral blood proteins by mass spectrometry and the transcriptome of activated, skin and gut-homing CD8+ T cells by gene expression profiling in aHSCT patients before the onset aGVHD, and an evaluation of the prognostic value of individual biomarkers or any cascade of events affected by disease progression.


Languages:

  • English (Level C1, 2005)
  • Italian (Beginner)

 

Publications

Selected publications: 

  • Unique patterns of CD8+ T cell-mediated organ damage in the Act-mOVA/OT-I model of acute graft versus host disease Cell Mol Life Sci. 2016 Apr 30. [Epub ahead of print], DOI: 10.1007/s00018-016-2237-7
  • Támadás a befogadó szervezet ellen, Nikolett Lupsa
    Élet és Tudomány, (Life and Science - Informative weekly Hungarian journal) 2016/25
  • Longevityfor free? Increased fecundity with limited trade-offs in Drosophila melanogastre selected for increased life span Experimental Gerontology
    Ms. Ref. No.: EXG-12-193


Complete list of publications:
 MTMT

 

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