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LajkoE

Position: Senior Research Fellow
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  Currently on maternity leave.
   

CV

Birth: 1983


Education:

  • 2006: Pharmacist (Pharm. D.), Faculty of Pharmacy, Semmelweis University
  • 2016: Pharmacology specialization, Faculty of Pharmacy, Semmelweis University


Academic qualifications:

  • 2013: Ph.D. in Pharmaceutics, School of Ph.D. Studies, Semmelweis University


Present and previous positions:

  • 2015- present: Research Fellow
    Department of Genetics, Cell- and Immunobiology, Semmelweis University
  • 2012 – 2015: Research Assistant
    Department of Genetics, Cell- and Immunobiology, Semmelweis University
  • 2008 – 2010: Resident Researcher
    Department of Pharmacodynamics, Semmelweis University
  • 2006 – 2012: Ph.D. student and intern
    Department of Genetics, Cell- and Immunobiology, Semmelweis University


Professional visits:

  • 2014 – 2015 (6 months): Biomedical Signalling Group, University of Applied Sciences Kaiserslautern, Campus Zweibrücken, Germany: Hungarian State Eötvös Scholarship
  • 2006 (1 month): Pharmaceutical practice, Poznan University of Medical Sciences, Poznan, Poland


Scholarship and awards:

  • 2016: Merit-award (6 months), Faculty of Medicine, Semmelweis University
  • 2014: Hungarian State Eötvös Scholarship (6 months), Balassi Institute
  • 2014: Publication award of Kisfaludy Lajos Foundation
  • 2011 and 2013: Award of the Doctoral Council at Scientific Symposium for Ph.D. Students at Semmelweis University
  • 2012: Award of the Dr. Rácz István Foundation
  • 2011: Predoctoral scholarship (6 months) of Aesculap Foundation
  • 2011: Predoctoral scholarship (6 months) of Centenary Foundation of Richter Gedeon Plc
  • 2010: Award of Dr. Mozsonyi Sándor Foundation


Activities in education:

  • Laboratory courses for 1st and 3rd year students at the Faculty of Medicine, Dentistry and Pharmacy at Semmelweis University in ”Medical Biology”, ”Basic Immunology”, as well as ”Genetics and Genomics” in Hungarian and English
  • ”Chemotaxis – its significance in biology and clinics” elective course at Semmelweis University
  • Supervisor or co-supervisor of undergraduate students working in research
  • Supervisor or co-supervisor of thesis-works
  • Reviewer of thesis-works


Research interests:

  • chemotaxis, cell adhesion, signalling
  • drug-targeting
  • impedimetry
  • hormonal imprinting


Research areas:

  • The effect of R-deprenyl and its derivatives as well as kinurenic acid and its analogs on the underlying cell physiological processes (adhesion, migration, proliferation) of endothelial repair - Investigations of the endothelial functions by impedance-based methods
    (Research grant by Semmelweis University, Faculty of Medicine ÁOK/DH/3804/2014)
  • In vitro investigations of the effects of bioconjugates for targeted tumor therapy of cancer types leading to high mortality
  • Investigation of the short and long term effects of vertebrate hormones on cell physiological activities of unicellular Tetrahymena. Study of the permanent character and the epigenetic inheritance of hormonal imprinting.


Languages:

  • Hungarian (native)
  • English
  • German

 

Publications

Selected publications: 

  • Lajkó E, Bányai P, Zámbó Z, Kursinszki L, Szőke E, Kőhidai L
    Targeted tumor therapy by Rubia tinctorum L.: analytical characterization of hydroxyanthraquinones and investigation of their selective cytotoxic, adhesion and migration modulator effects on melanoma cell lines (A2058 and HT168 M1) Cancer Cell International 15: Paper 119. 15 p. (2015)
  • Enyedi KN, Czajlik A, Knapp K, Láng A, Majer Z, Lajkó E, Kőhidai L, Perczel A, Mező G
    Development of Cyclic NGR Peptides with Thioether Linkage: Structure and Dynamics Determining Deamidation and Bioactivity. Journal of Medicinal Chemistry 58: pp. 1806-1817. (2015)
  • Kőhidai L, Lajkó E, Szabó I, Polgár L, Manea M, Mező G
    GnRH based drug targeting - Cell adhesion and migration modulator effects of GnRH derivatives in tumour cells. (Co-first author)
    In: Sills ES (szerk) Gonadotropin-Releasing Hormone (GnRH): Production, Structure, and Function. New York: Nova Scientific Publishers, 2013. pp. 254-272.
  • Lajkó E, Szabó I, Anódy K, Pungor A, Mező G, Kőhidai L
    Investigation on chemotactic drug targeting (chemotaxis and adhesion) inducer effect of GnRH-III derivatives in Tetrahymena and human leukemia cell line. Journal Of Peptide Science 19:(1) pp. 46-58. (2013)
  • Lajkó E, Polgár L, Láng O, Lengyel J, Kőhidai L, Magyar K
    Basic cell physiological activities (cell adhesion, chemotaxis and proliferation) induced by selegiline and its derivatives in Mono Mac 6 human monocytes. Journal of Neural Transmission 119:(5) pp. 545-556. (2012)
  • Leurs U, Lajkó E, Mező G, Orbán E, Öhlschläger C P, Marquardt A, Kőhidai L,
    Manea M GnRH-III based multifunctional drug delivery systems containing daunorubicin and methotrexate European Journal of Medicinal Chemistry 52: pp. 173-183. (2012) (Co-first author)


Complete list of publications:
MTMTPubMed

 

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