About the group
Colorectal cancer (CRC) is one of the leading causes of cancer related death in Hungary and in the Western countries. Despite the progress in understanding colorectal tumorigenesis, this disease still represents an outstanding health problem. Recent reports have proved that not only the tumor cells, but also the stromal cells critically contribute to the tumor progression and patient survival.
The 5-year patient survival is extremely low in pancreatic and lung cancers, partially due to the late diagnosis and the lack of early signs of these diseases.
Our mission is to identify novel communication mechanisms between tumor cells and the stroma that can form the basis of future therapeutic interventions in CRC, pancreatic ductal adenocarcinoma (PDAC) and lung cancer. Furthermore, we aim at identifying novel early biomarkers for lung and pancreatic cancers. One of our interests is the function of the extracellular vesicles that represent a novel form of cell-to-cell communication.
We use a large array of state-of-the-art methods to answer our biological questions, such as the patient-derived organoid technology and the genome editing CRISPR-Cas9 method. Our research group is financed by grants from the Semmelweis University and from the National Research, Development and Innovation Office (Hungary).
Members
Leader:
Members:
|
|
Dr. Szabolcs Hajdó MD, PhD student |
|
|
Dr. Idan Carmi MD, PhD student |
|
Undergraduate students
|
Adrián Orosz, MD-PhD student
Réka Kormány, Pharma student
Regina Szász, MSc student
Maya Litner, MD student
|
|
Former
members
|
Kata Barabás, MD student
Dániel Szabó, MD student
Iván Seress, MD student
Ádám Nagy, MD
István Kovács, MD
Lili Szabó, MSc
Márton Pápai, MSc
Anna Kiss, MD
Zsuzsanna Szvicsek, PhD (2021)
Ádám Oszvald, PhD (2021)
Gyöngyvér Orsolya Sándor, PhD (2022)
Andrea Kelemen, PhD (2022)
András Áron Soós (2023)
|
Selected publications
- Benke M, Zeöld A, Kittel Á, Khamari D, Hritz I, Horváth M, Keczer B, Borka K, Szücs Á, Wiener Z (2023) MiR-200b categorizes patients into pancreas cystic lesion subgroups with different malignant potential. Sci Rep.13(1):19820. IF: 4,997
- Soós AÁ, Kelemen A, Orosz A, Szvicsek Z, Tölgyes T, Dede K, Bursics A, Wiener Z (2023) High CD142 Level Marks Tumor-Promoting Fibroblasts with Targeting Potential in Colorectal Cancer.
Int J Mol Sci. 24(14):11585. IF: 6,2
- Kelemen A, Carmi I, Seress I, Lőrincz P, Tölgyes T, Dede K, Bursics A, Buzás EI, Wiener Z (2022) CD44 Expression Intensity Marks Colorectal Cancer Cell Subpopulations with Different Extracellular Vesicle Release Capacity. Int J Mol Sci. 2022 Feb 16;23(4):2180. IF: 6.2
-
Kelemen A, Carmi I, Oszvald Á, Lőrincz P, Petővári G, Tölgyes T, Dede K, Bursics A, Buzás EI, Wiener Z (2021) IFITM1 expression determines extracellular vesicle uptake in colorectal cancer. Cell Mol Life Sci. 2021 Oct 5. doi: 10.1007/s00018-021-03949-w. IF: 9.261
- Sándor GO, Soós AÁ, Lörincz P, Rojkó L, Harkó T, Bogyó L, Tölgyes T, Bursics A, Buzás EI, Moldvay J, Wiener Z (2021) Wnt Activity and Cell Proliferation Are Coupled to Extracellular Vesicle Release in Multiple Organoid Models. Front Cell Dev Biol. 2021;9:670825. doi: 10.3389/fcell.2021.670825. eCollection 2021. IF: 6.684
- Zeöld A, Sándor GO, Kiss A, Soós AÁ, Tölgyes T, Bursics A, Szűcs Á, Harsányi L, Kittel Á, Gézsi A, Buzás EI, Wiener Z (2021) Shared extracellular vesicle miRNA profiles of matched ductal pancreatic adenocarcinoma organoids and blood plasma samples show the power of organoid technology. Cell Mol Life Sci. 2020 Nov 25. doi: 10.1007/s00018-020-03703-8. IF: 9.261
- Oszvald Á, Szvicsek Z, Pápai M, Kelemen A, Varga Z, Tölgyes T, Dede K, Bursics A, Buzás EI, Wiener Z (2020) Fibroblast-Derived Extracellular Vesicles Induce Colorectal Cancer Progression by Transmitting Amphiregulin. Front Cell Dev Biol. https://doi.org/10.3389/fcell.2020.00558. IF: 5.201
- Oszvald Á, Szvicsek Z, Sándor GO, Kelemen A, Soós AÁ, Pálóczi K, Bursics A, Dede K, Tölgyes T, Buzás EI, Zeöld A, Wiener Z (2020) Extracellular vesicles transmit epithelial growth factor activity in the intestinal stem cell niche. Stem Cells. 38(2):291-300. IF: 6.022
- Szvicsek Z, Oszvald Á, Szabó L, Sándor GO, Kelemen A, Soós AÁ, Pálóczi K, Harsányi L, Tölgyes T, Dede K, Bursics A, Buzás EI, Zeöld A, Wiener Z (2019). Extracellular vesicle release from intestinal organoids is modulated by Apc mutation and other colorectal cancer progression factors. Cell Mol Life Sci. 76(12):2463-2476. IF: 6.496
- Lupsa N, Érsek B, Horváth A, Bencsik A, Lajkó E, Silló P, Oszvald Á, Wiener Z, Reményi P, Mikala G, Masszi T, Buzás EI, Pós Z (2018). Skin-homing CD8+ T cells preferentially express GPI-anchored peptidase inhibitor 16, an inhibitor of cathepsin K. Eur J Immunol. 2018 Dec;48(12):1944-1957. IF: 4,248
- Högström J, Heino S, Kallio P, Lähde M, Leppänen VM, Balboa D, Wiener Z*, Alitalo K* (2018). Transcription factor PROX1 suppresses Notch pathway activation via the nucleosome remodeling and deacetylase complex in colorectal cancer stem-like cells. Cancer Res. 2018 Oct 15;78(20):5820-5832. IF: 9,13. *shared last authorship
- Osteikoetxea X, Benke M, Rodriguez M, Pálóczi K, Sódar BW, Szvicsek Z, Szabó-Taylor K, Vukman KV, Kittel Á, Wiener Z, Vékey K, Harsányi L, Szűcs Á, Turiák L, Buzás EI. (2018) Detection and proteomic characterization of extracellular vesicles in human pancreatic juice. Biochem Biophys Res Commun. 2018 Apr 30;499(1):37-43. IF: 2,56
- Németh A, Orgovan N, Sódar BW, Osteikoetxea X, Pálóczi K, Szabó-Taylor KÉ, Vukman KV, Kittel Á, Turiák L, Wiener Z, Tóth S, Drahos L, Vékey K, Horvath R, Buzás EI. (2017). Antibiotic-induced release of small extracellular vesicles (exosomes) with surface-associated DNA. Sci Rep, 7, 8202. IF: 4.259.
-
Kivelä R, Salmela I, Nguyen YH, Petrova TV, Koistinen HA, Wiener Z, Alitalo K (2016). The transcription factor Prox1 is essential for satellite cell differentiation and muscle fibre-type regulation. Nat Commun, 7, 13124. IF: 11.329.
-
Sodar B, Kittel A, Paloczi K, Vukman K, Osteikoetxea X, Szabó-Taylor K, Nemeth A, Sperlágh B, Baranyai T, Giricz Z, Wiener Z, Turiak L, Drahos L, Pallinger E, Vekey K, Ferdinandy P, Falus A, Buzas EI (2016). Low-density lipoprotein mimics blood plasma-derived exosomes and microvesicles during isolation and detection. Sci Rep, 6, 24316. IF: 5.578
- Tamminen K, Balboa D, Toivonen S, Pakarinen MP, Wiener Z, Alitalo K, Otonkoski T (2015). Intestinal Commitment and Maturation of Human Pluripotent Stem Cells Is Independent of Exogenous FGF4 and R-spondin1. PLoS One, 10, e0134551. IF: 3.234
- Szmolka A, Wiener Z, Matulova ME, Varmuzova K, Rychlik I (2015). Gene Expression Profiles of Chicken Embryo Fibroblasts in Response to Salmonella Enteritidis Infection. PLoS One, 10, e0127708. IF: 3.234
- Wiener Z, Högström J, Hyvönen V, Band AM, Kallio P, Holopainen T, Dufva O, Haglund C, Kruuna O, Oliver G, Ben-Neriah Y, Alitalo K (2014). Prox1 promotes expansion of the colorectal cancer stem cell population to fuel tumor growth and ischemia resistance. Cell Rep, 8, 1943-56. IF: 8.358
- Wiener Z, Band AM, Kallio P, Högström J, Hyvönen V, Kaijalainen S, Ritvos O, Haglund C, Kruuna O, Robine S, Louvard D, Ben-Neriah Y, Alitalo K (2014). Oncogenic mutations in intestinal adenomas regulate Bim-mediated apoptosis induced by TGF-β. Proc Natl Acad Sci USA, 111, E2229-36. IF: 9.674
- Gilicze AB, Wiener Z, Tóth S, Buzás E, Pállinger E, Falcone FH, Falus A (2014). Myeloid-Derived microRNAs, miR-223, miR27a, and miR-652, Are Dominant Players in Myeloid Regulation. Biomed Res Int. 2014:870267. Review. IF: 1.579
- Pribluda A, Elyada E, Wiener Z, Hamza H, Goldstein RE, Biton M, Burstain I, Morgenstern Y, Brachya G, Billauer H, Biton S, Snir-Alkalay I, Vucic D, Schlereth K, Mernberger M, Stiewe T, Oren M, Alitalo K, Pikarsky E, Ben-Neriah Y (2013). A senescence-inflammatory switch from cancer-inhibitory to cancer-promoting mechanism. Cancer Cell, 24, 242-56. IF: 23.893
- Holopainen T, López-Alpuche V, Zheng W, Heljasvaara R, Jones D, He Y, Tvorogov D, D'Amico G, Wiener Z, Andersson LC, Pihlajaniemi T, Min W, Alitalo K (2012). Deletion of the endothelial Bmx tyrosine kinase decreases tumor angiogenesis and growth. Cancer Res, 72, 3512-21. IF: 8.650
- Molnár V, Érsek B, Wiener Z, Tömböl Z, Szabó PM, Igaz P, Falus A (2012). MicroRNA-132 targets HB-EGF upon IgE-mediated activation in murine and human mast cells. Cell Mol Life Sci, 69, 793-808. IF: 5.615
- Elyada E, Pribluda A, Goldstein RE, Morgenstern Y, Brachya G, Cojocaru G, Snir-Alkalay I, Burstain I, Haffner-Krausz R, Jung S, Wiener Z, Alitalo K, Oren M, Pikarsky E, Ben-Neriah Y (2011). CKIα ablation highlights a critical role for p53 in invasiveness control. Nature, 470, 409-13. IF: 36.280
- Szabó PM, Wiener Z, Tömböl Z, Kovács A, Pócza P, Horányi J, Kulka J, Riesz P, Tóth M, Patócs A, Gaillard RC, Falus A, Rácz K, Igaz P (2009). Differences in the expression of histamine-related genes and proteins in normal human adrenal cortex and adrenocortical tumors. Virchows Arch, 455, 133-42. IF: 2.305
- Tölgyesi G, Molnár V, Semsei AF, Kiszel P, Ungvári I, Pócza P, Wiener Z, Komlósi ZI, Kunos L, Gálffy G, Losonczy G, Seres I, Falus A, Szalai C (2009). Gene expression profiling of experimental asthma reveals a possible role of paraoxonase-1 in the disease. Int Immunol, 21, 967-75. IF: 3.403
- Tömböl Z, Szabó P, Molnár V, Wiener Z, Tölgyesi G, Horànyi J, Riesz P, Reismann P, Patócs A, Likó I, Gaillard R, Falus A, Racz K, Igaz P (2009). Integrative molecular-bioinformatics study of human adrenocortical tumors: microRNA, tissue specific target prediction and pathway analysis. Endocr Relat Cancer, 16, 895-906. IF: 4.282
- Wiener Z, Pocza P, Racz M, Nagy G, Tolgyesi G, Molnar V, Jaeger J, Buzas E, Gorbe E, Papp Z, Rigo J, Falus A (2008). IL-18 induces a marked gene expression profile change and increased Ccl1 (I-309) production in mouse mucosal mast cell homologs. Int Immunol. 20: 1565-73. IF: 3.181
- Molnar V, Tamasi V, Bakos B, Wiener Z, Falus A (2008). Changes in miRNA expression in solid tumors: An miRNA profiling in melanomas. Semin Cancer Biol. 18: 111-22. IF: 8.284
- György B, Tóthfalusi L, Nagy G, Pásztói M, Géher P, Lörinc Z, Polgár A, Rojkovich B, Ujfalussy I, Poór G, Pócza P, Wiener Z, Misják P, Koncz A, Falus A, Buzás EI (2008). Natural autoantibodies reactive with glycosaminoglycans in rheumatoid arthritis. Arthritis Res Ther. 10, R110. IF: 4.485
- Pos Z, Wiener Z, Pocza P, Racz M, Toth S, Darvas Z, Molnar V, Hegyesi H, Falus A (2008). Histamine suppresses fibulin-5 and insulin-like growth factor-II receptor expression in melanoma. Cancer Res 68:1997-2005. IF: 7.514
- Gilicze A, Kohalmi B, Pocza P, Keszei M, Jaeger J, Gorbe E, Papp Z, Toth S, Falus A, Wiener Z (2007). HtrA1 is a novel mast cell serine protease of mice and men. Mol Immunol. 44, 2961-8. IF: 3.742
- Wiener Z, Kohalmi B, Pocza P, Jeager J, Tolgyesi G, Toth S, Gorbe E, Papp Z, Falus A (2007). The immunoregulatory TIM-3 is expressed in melanoma cells and is upregulated in TGF-beta stimulated mast cells. J Invest Dermatol. 127, 906-14. IF: 4.829
- Igaz P, Wiener Z, Szabo P, Falus A, Gaillard RC, Horanyi J, Racz K, Tulassay Z (2006). Functional genomics approaches for the study of sporadic adrenal tumor pathogenesis: Clinical implications. J Steroid BiochemMol Biol 101, 87-96. Review. IF: 2.825
- Wiener Z, Ontsouka EC, Jakob S, Torgler R, Falus A, Mueller C, Brunner T (2004). Synergistic induction of the Fas (CD95) ligand promoter by Max and NFkappaB in human non-small lung cancer cells. Exp Cell Res 299, 227-35. IF: 4.007
- Wiener Z, Falus A, Toth S (2004). IL-9 increases the expression of several cytokines in activated mast cells, while the IL9 induced IL-9 production is inhibited in mast cells of histamine-free transgenic mice. Cytokine 26, 122-30. IF: 1.986
- Wiener Z, Andrásfalvy M, Pállinger E, Kovács P, Szalai Cs, Erdei A, Toth S, Nagy A, Falus A (2002). Bone marrow-derived mast cell differentiation is strongly reduced in histidine decarboxylase knockout, histamine-free mice. Int Immunol, 14, 381-87. IF: 3.595
Collaborators
- Prof. Kari Alitalo, Research Programs Units, University of Helsinki, Finland
- Prof. László Harsányi, Dr. Ákos Szűcs, 1st Department of Surgery, Semmelweis University, Budapest, Hungary
- Dr. Tamás Beke-Somfai, Institute of Materials and Environmental Chemistry, Hungarian Academy of Sciences
- Dr. Attila Bursics, Dr. Kristóf Dede, Dr. Tamás Tölgyes, Uzsoki Hospital, Budapest, Hungary
- Dr. Judit Moldvay, Korányi National Institute for Pulmonology, Budapest, Hungary
- Prof. Edit Buzás, Department of Genetics, Cell and Immunobiology, Semmelweis University, Budapest, Hungary