Topic list
GENETICS OF SEX (elective subject)
2017/18 2nd Semester
Week
|
Lecture
Monday, 17:50 - 19:20 Brown Lecture Hall
|
1st week
(5 - 9 Feb)
|
-----------------
|
2nd week
(12 - 16 Feb)
|
Genetic background of sex determination; From sex determining gene to sex chromosome

|
3rd week
(19 - 23 Feb)
|
Male and female sex determination

|
4th week
(26 Feb - 2 Mar)
|
Abnomalities in sex determination I.

|
5th week
(5 - 9 Mar)
|
Abnomalities in sex determination II.

|
6th week
(12 - 16 Mar)
|
Abnomalities in sex determination III. Non-sex-linked disorders with abnomalities in sex determination

|
7th week
(19 - 23 Mar)
|
Epigenetic effects; Genome imprinting

|
(26 - 30 Mar)
|
Easter holiday
|
8th week
(2 - 6 Apr)
|
Easter Monday
|
9th week
(9 - 13 Apr)
|
Mechanism and role of X inactivation

|
10th week
(16 - 20 Apr)
|
Sex influence on heredity
 |
11th week
(23 - 27 Apr)
|
Y chromosome mutations and ICSI; Importance of Y chromosomal and mitochondrial polymorphisms in population genetics

|
12th week
(30 Apr - 4 May)
|
National holiday
|
13th week
(7 - 11 May)
|
Aggressivity and sex; Homo- or heterosexuality

|
14th week
(14 - 18 May)
|
Ecology and sex; role of endocrine disruptors; what future brings

|
The exam grade will be based on a written test at the end of the semester. The test questions will cover the topics of the lecture presentations.
Lecturer: Sara Tóth PhD, associate professor
NET Building, 6th floor, room 619.
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: +36 1 210 2930 / 56244
Recommended literature
- Co-evolution of X-chromosome inactivation and imprinting in mammals.
Reik W, Lewis A.
Nat Rev Genet. 2005 May;6(5):403-10. Review.
- X-chromosome inactivation: a hypothesis linking ontogeny and phylogeny.
Huynh KD, Lee JT.
Nat Rev Genet. 2005 May;6(5):410-8. Review
- Gilbert: Developmental Biology, 6th ed., 2000
Ch17. Sex determination
Ch.3. Environmental development biology
Environmental sex determination
http://www.ncbi.nlm.nih.gov/books/
- http://10e.devbio.com
- Syndromal (and nonsyndromal) forms of male pseudohermaphroditism.
Neri G, Opitz J.
Am J Med Genet. 1999 Dec 29;89(4):201-9. Review.
- Minireview: Hormones and Human Sexual Orientation.
Baltazart J.
Endocrinology 2011. 1152. 2937. -2947.
- Sperm counts and fertility in men: a rocky road ahead.
Sharpe M.R.
EMBO Reports 2012. 13. (5) 398.-403.
- Endocrine disruptors.
WHO/UNEP
- Environmental influences on ovarian dysgenesis - developmental windows sensitive to chemical exposures.
Johansson HKL, Svingen T, Fowler PA, Vinggaard AM, Boberg J.
Nat Rev Endocrinol. 2017 Apr 28. Review.
Other readings for enthusiasts only:
-
Colapinto J.: As Nature Made Him: The Boy Who Was Raised As A Girl. 2000. Harper Collins Inc., ISBN 0-06-092959-6
-
Jones S.: Y. The descent of man. 2003. Houghton Mifflin , ISBN 0-618-56561-2
-
Ridley M.: The Red Queen: Sex and the Evolution of Human Nature. 2003 Haper Perennial, ISBN-10: 0060556579