Topic list
GENETICS OF SEX (elective subject)
2018/19 2nd Semester
Week
|
Lecture
Monday, 17:50 - 19:20 Brown Lecture Hall
|
1st week
(4 - 8 Feb)
|
-----------------
|
2nd week
(11 - 15 Feb)
|
Asexual versus sexual reproduction
|
3rd week
(18 - 22 Feb)
|
From sex determining gene to sex chromosome
|
4th week
(25 Feb - 1 Mar)
|
Male and female sex determination
|
5th week
(4 - 8 Mar)
|
Abnomalities in sex determination I.
|
6th week
(11 - 14 Mar)
|
Abnomalities in sex determination II.
|
7th week
(18 - 22 Mar)
|
Abnomalities in sex determination III.
|
8th week
(25 - 29 Mar)
|
Epigenetic effects; Genome imprinting
|
9th week
(1 - 5 Apr)
|
Mechanism and role of X inactivation
|
10th week
(8 - 12 Apr)
|
Mitochondrial and Y chromosomal polymorphisms; Y chromosome mutations
|
(15 - 19 Apr)
|
Easter Holiday |
11th week
(22 - 26 Apr)
|
Easter Monday
|
12th week
(29 Apr - 3 May)
|
Aggressivity and sex; Homo- or heterosexuality
|
13th week
(6 - 10 May)
|
Infertility
|
14th week
(13 - 17 May)
|
Ecology and sex; role of endocrine disruptors
|
The exam grade will be based on a written test at the end of the semester. The test questions will cover the topics of the lecture presentations.
Lecturer: Sara Tóth PhD, associate professor
NET Building, 6th floor, room 619.
Email: This email address is being protected from spambots. You need JavaScript enabled to view it.
Phone: +36 1 210 2930 / 56244
Recommended literature
- Co-evolution of X-chromosome inactivation and imprinting in mammals.
Reik W, Lewis A.
Nat Rev Genet. 2005 May;6(5):403-10. Review.
- X-chromosome inactivation: a hypothesis linking ontogeny and phylogeny.
Huynh KD, Lee JT.
Nat Rev Genet. 2005 May;6(5):410-8. Review
- Gilbert: Developmental Biology, 6th ed., 2000
Ch17. Sex determination
Ch.3. Environmental development biology
Environmental sex determination
http://www.ncbi.nlm.nih.gov/books/
- http://10e.devbio.com
- Syndromal (and nonsyndromal) forms of male pseudohermaphroditism.
Neri G, Opitz J.
Am J Med Genet. 1999 Dec 29;89(4):201-9. Review.
- Minireview: Hormones and Human Sexual Orientation.
Baltazart J.
Endocrinology 2011. 1152. 2937. -2947.
- Sperm counts and fertility in men: a rocky road ahead.
Sharpe M.R.
EMBO Reports 2012. 13. (5) 398.-403.
- Endocrine disruptors.
WHO/UNEP
- Environmental influences on ovarian dysgenesis - developmental windows sensitive to chemical exposures.
Johansson HKL, Svingen T, Fowler PA, Vinggaard AM, Boberg J.
Nat Rev Endocrinol. 2017 Apr 28. Review.
Other readings for enthusiasts only:
-
Colapinto J.: As Nature Made Him: The Boy Who Was Raised As A Girl. 2000. Harper Collins Inc., ISBN 0-06-092959-6
-
Jones S.: Y. The descent of man. 2003. Houghton Mifflin , ISBN 0-618-56561-2
-
Ridley M.: The Red Queen: Sex and the Evolution of Human Nature. 2003 Haper Perennial, ISBN-10: 0060556579