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PosZ

Position: Associate Professor
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Room: NET 709
Phone: +36 (1) 210 2930 / 56435
   

CV

Birth: 1977, Budapest, Hungary

Education:

  • Eötvös Loránd University of Sciences, Budapest, Hungary, biologist (immunologist)

Academic qualifications:

  • 2005: PhD in Biology, Semmelweis University School of Doctoral Studies, Molecular Medicine Doctoral School, Budapest, Hungary 
  • 2000: MSc in Biology, Eötvös Loránd University of Sciences, Budapest, Hungary

Present and previous positions:

  • 2016-present: Semmelweis University, Department of Genetics Cell, and Immunobiology, Budapest, assiociate professor
  • 2012-2016: HAS-SU ”Momentum” Experimetal and Translational Immunomics Research Group, group leader
  • 2010-2016: Semmelweis University, Department of Genetics Cell, and Immunobiology, Budapest, assistant professor
  • 2007-2010: Infectious Disease and Immunogenetics Section, DTM, Clinical Center, NIH, Bethesda, MD, USA, postdoctoral visiting fellow
  • 2006-2007: Semmelweis University, Department of Genetics Cell, and Immunobiology, Budapest, instructor
  • 2005-2006: Semmelweis University, Department of Genetics Cell, and Immunobiology, Budapest, intern
  • 2004-2005: Hungarian Defence Forces, Institute of Health Protection, Department of Pathophysiology, research assistant
  • 2001-2004: Hungarian Academy of Sciences - Semmelweis University Molecular Immunology Research Group, Budapest, research assistant
  • 2000-2000: Institut für Medizinische Mikrobiologie und Hygiene, Universtität zu Lübeck, Lübeck, Germany, DAAD-fellow

Professional visits:

  • 2007-2010: Infectious Disease and Immunogenetics Section, DTM, Clinical Center, NIH, Bethesda, MD, USA, postdoctoral visiting fellow 
  • 2000-2000: Institut für Medizinische Mikrobiologie und Hygiene, Universtität zu Lübeck, Lübeck, Germany, DAAD-fellow

Honours and awards:

  • 2017 Semmelweis University Research Excellence Award
  • 2011 Hungarian Academy of Sciences, Janos Bolyai Research Stipend

Memberships:

  • Hungarian Society for Immunology, board member
  • Hungarian Cancer Society, member

Activities in education:
Participates in the Hungarian, German and English language training program of medical students at the Semmelweis University, Budapest, Hungary. Lectures Immunology, Medical Cell Biology and Genetics.

Research interests:
Investigation of CD8+ resident memory T cells (CD8+ Trm) and organ-specific differences in CD8+ T cell-mediated immunity by genomic scale gene expression analysis, large scale data processing, high throughput statistical and functional bioinformatic analysis.
Research areas:

Languages:

  • English (advanced level, TOEFL)
  • German (advanced level, ZOP)
  • Latin (ITK type "B")

 

 

 

 

Publications

Most relevant publications:

  • Lupsa N, Érsek B, Horváth A, Bencsik A, Lajkó E, Silló P, Oszvald Á, Wiener Z, Reményi P, Mikala G, Masszi T, Buzás EI, Pós Z. Skin-homing CD8+ T cells preferentially express GPI-anchored peptidase inhibitor 16, an inhibitor of cathepsin K. Eur J Immunol. 2018 Dec;48(12):1944-1957.
  • Érsek B, Lupsa N, Pócza P, Tóth A, Horváth A, Molnár V, Bagita B, Bencsik A, Hegyesi H, Matolcsy A, Buzás EI, Pós Z. Unique patterns of CD8+ T-cell-mediated organ damage in the Act-mOVA/OT-I model of acute graft-versus-host disease. Cell Mol Life Sci. 2016 Oct;73(20):3935-47
  • Tsang JS, Schwartzberg PL, Kotliarov Y, Biancotto A, Xie Z, Germain RN, Wang E, Olnes MJ, Narayanan M, Golding H, Moir S, Dickler HB, Perl S, Cheung F; Collaborators: Obermoser G, Chaussabel D, Palucka K, Chen J, Fuchs JC, Ho J, Khurana S, King LR, Langweiler M, Liu H, Manischewitz J, Pos Z, Posada JG, Schum P, Shi R, Valdez J, Wang W, Zhou H, Kastner DL, Marincola FM, McCoy JP, Trinchieri G, Young NS. Global analyses of human immune variation reveal baseline predictors of postvaccination responses. Cell. 2014 Apr 10;157(2):499-513
  • Pos Z, Spivey TL, Liu H, Sommariva M, Chen J, Wunderlich JR, Parisi G, Tomei S, Ayotte BD, Stroncek DF, Malek JA, Robbins PF, Rivoltini L, Maio M, Chouchane L, Wang E, Marincola FM.Longitudinal study of recurrent metastatic melanoma cell lines underscores the individuality of cancer biology. J Invest Dermatol. 2014 May;134(5):1389-96
  • Ji Y, Pos Z, Rao M, Klebanoff CA, Yu Z, Sukumar M, Reger RN, Palmer DC, Borman ZA, Muranski P, Wang E, Schrump DS, Marincola FM, Restifo NP, Gattinoni L. Repression of the DNA-binding inhibitor Id3 by Blimp-1 limits the formation of memory CD8(+) T cells. Nat Immunol. 2011;12(12):1230-7
  • Gattinoni L, Lugli E, Ji Y, Pos Z, Paulos CM, Quigley MF, Almeida JR, Gostick E, Yu Z, Carpenito C, Wang E, Douek DC, Price DA, June CH, Marincola FM, Roederer M, Restifo NP. A human memory T cell subset with stem cell-like properties. Nat Med. 2011;17(10):1290-7
  • Pos Z, Selleri S, Spivey TL, Wang JK, Liu H, Worschech A, Sabatino M, Monaco A, Leitman SF, Falus A, Wang E, Alter HJ, Marincola FM. Genomic scale analysis of racial impact on response to IFN-alpha. Proc Natl Acad Sci USA. 2010;107(2):803-8
  • Pos Z, Wiener Z, Pocza P, Racz M, Toth S, Darvas Z, Molnar V, Hegyesi H, Falus A. Histamine suppresses fibulin-5 and insulin-like growth factor-II receptor expression in melanoma. Cancer Res 2008;68(6):1997-2005
  • Pos Z, Safrany G, Muller K, Toth S, Falus A, Hegyesi H. Phenotypic profiling of engineered mouse melanomas with manipulated histamine production identifies histamine H2 receptor and rho-C as histamine-regulated melanoma progression markers. Cancer Res 2005; 65(10):4458-66

Complete list of publications: MTMTPubMedGoogle Scholar

 
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